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Article

Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides.

Nature - 1 Aug 2018

Wan Xiaoxiao, Zinselmeyer Bernd H, Zakharov Pavel N, Vomund Anthony N, Taniguchi Ruth, Santambrogio Laura, Anderson Mark S, Lichti Cheryl F, Unanue Emil R

Abstract excerpt

Tissue-specific autoimmunity occurs when selected antigens presented by susceptible alleles of the major histocompatibility complex are recognized by T cells. However, the reason why certain specific self-antigens dominate the response and are indispensable for triggering autoreactivity is unclear. Spontaneous presentation of insulin is essential for initiating autoimmune type 1 diabetes in non-obese diabetic...

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Share to Antigen Presentation
Share to Cytoplasmic Granules

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30022165
DOI: 10.1038/s41586-018-0341-6
PMCID: PMC6090537

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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