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Article

Cellular heterogeneity during mouse pancreatic ductal adenocarcinoma progression at single-cell resolution

23 Jul 2019

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDA) is a major cause of cancer-related death with limited therapeutic options available. This highlights the need for improved understanding of the biology of PDA progression, a highly complex and dynamic process featuring changes in cancer cells and stromal cells. A comprehensive characterization of PDA cancer cell and stromal cell heterogeneity during disease progression is...

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PMID: 31335328
DOI: 10.1172/jci.insight.129212

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