Article

Molecular determinant of sterol recognition by sterol cleavage activatory protein

2024-11-21

Abstract excerpt

Intracellular cholesterol homeostasis is regulated by the sterol response element-binding protein (SREBP) pathway through the SREBP cleavage-activating protein (SCAP) and the insulin-induced gene protein (INSIG). Previous studies highlighted that high concentrations of cholesterol mediated the dimerisation between INSIG and SCAP, which led to an inhibition of cholesterol uptake and biogenesis. However, the molecul...

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Literature Corpus work: e08d3af3-9d9c-583a-b12c-d5fac888bea5
DOI: 10.1101/2024.11.19.624286

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