Article

STARD3 mediates non-vesicular cholesterol transport in <i>Caenorhabditis elegans</i>

2026-01-12

Abstract excerpt

Cholesterol transport plays a pivotal role in regulating development and metabolism in Caenorhabditis elegans , a sterol-auxotrophic organism. Here, we identify the nematode cholesterol-binding protein STARD3 and provide structural and functional evidence for its role in non-vesicular sterol mobilization. Using biophysical and high-resolution structural methods, we show that the START domain (Ce-START) of C. ele...

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Literature Corpus work: 44fa9d75-455c-523d-b70f-15e67893d1c8
DOI: 10.64898/2026.01.09.698688

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