Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins.

Proceedings of the National Academy of Sciences of the United States of America - 1 Oct 2002

Yabe Daisuke, Brown Michael S, Goldstein Joseph L

Abstract excerpt

This paper describes insig-2, a second protein of the endoplasmic reticulum that blocks the processing of sterol regulatory element-binding proteins (SREBPs) by binding to SCAP (SREBP cleavage-activating protein) in a sterol-regulated fashion, thus preventing it from escorting SREBPs to the Golgi. By blocking this movement, insig-2, like the previously described insig-1, prevents the proteolytic processing of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Northern
Share to CCAAT-Enhancer-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CHO Cells

Share to Cholesterol

Share to Endoplasmic Reticulum

Share to Golgi Apparatus

Share to Precipitin Tests

Share to Sterol Regulatory Element Binding Protein 1

Source

Open in PubMed Open full text

Identifiers

PMID: 12242332
DOI: 10.1073/pnas.162488899
PMCID: PMC130532

Genes

SCAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins.PMID 12242332Read ↗

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER.Semantic proximity Read ↗

Intramembrane glycine mediates multimerization of Insig-2, a requirement for sterol regulation in Chinese hamster ovary cells.Semantic proximity Read ↗

Isolation of sterol-resistant Chinese hamster ovary cells with genetic deficiencies in both Insig-1 and Insig-2.Semantic proximity Read ↗

Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro.Semantic proximity Read ↗

SREBPs: sterol-regulated transcription factorsSemantic proximity Read ↗

Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.Semantic proximity Read ↗

A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols.Semantic proximity Read ↗

Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis.Semantic proximity Read ↗

Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols.Semantic proximity Read ↗

Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1.Semantic proximity Read ↗

A novel processing system of sterol regulatory element-binding protein-1c regulated by polyunsaturated fatty acid.Semantic proximity Read ↗

Proteasomal degradation of ubiquitinated Insig proteins is determined by serine residues flanking ubiquitinated lysines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.