Article
Molecular basis for the recognition of steroidogenic acute regulatory protein by the 14-3-3 protein family.
The FEBS journal - 1 Sept 2020
Tugaeva Kristina V, Titterington James, Sotnikov Dmitriy V, Maksimov Eugene G, Antson Alfred A, Sluchanko Nikolai N
Abstract excerpt
Steroidogenesis in adrenals and gonads starts from cholesterol transport to mitochondria. This is mediated by the steroidogenic acute regulatory protein (STARD1), containing a mitochondrial import sequence followed by a cholesterol-binding START domain. Although mutations in this protein have been linked to lipoid congenital adrenal hyperplasia (LCAH), the mechanism of steroidogenesis regulation by STARD1 remains...
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