Article

Structural basis for the HMGCR interaction with UBIAD1 mutants causing Schnyder corneal dystrophy

2020-06-29

Abstract excerpt

Schnyder corneal dystrophy (SCD) is an autosomal dominant disease characterized by abnormal deposition of cholesterol and lipid in the cornea. The molecular mechanism underlying this process, which involves the interaction between UBAID1 and HMGCR, remains unclear. Here we investigate these events with in silico approaches. We built the homology models of UBIAD1 and HMGCR based on the existing crystal and cryo-EM...

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Literature Corpus work: 858d8de0-6d7c-5b0c-974d-b37fe8a5b53c
DOI: 10.1101/2020.06.29.177683

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