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Article

A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols.

Science (New York, N.Y.) - 5 Mar 2021

Yan Renhong, Cao Pingping, Song Wenqi, Qian Hongwu, Du Ximing, Coates Hudson W, Zhao Xin, Li Yaning, Gao Shuai, Gong Xin, Liu Ximing, Sui Jianhua, Lei Jianlin, Yang Hongyuan, Brown Andrew J, Zhou Qiang, Yan Chuangye, Yan Nieng

Abstract excerpt

The sterol regulatory element-binding protein (SREBP) pathway controls cellular homeostasis of sterols. The key players in this pathway, Scap and Insig-1 and -2, are membrane-embedded sterol sensors. The 25-hydroxycholesterol (25HC)-dependent association of Scap and Insig acts as the master switch for the SREBP pathway. Here, we present cryo-electron microscopy analysis of the human Scap and Insig-2 complex in...

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PMID: 33446483
DOI: 10.1126/science.abb2224

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