Article
Niemann-Pick type C1 protein influences the delivery of cholesterol to the SREBP:SCAP complex.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 1 Jan 2008
Guo Y J, Li W H, Wu R, Xie Q, Zhang Z H, Cui L Q
Abstract excerpt
The proposed role of Niemann-Pick type C1 protein (NPC1) in the delivery of low-density lipoprotein (LDL) cholesterol to the sterol regulatory element binding protein (SREBP):SREBP cleavage activation protein (SCAP) complex in the endoplasmic reticulum has been largely based on indirect studies and remains contentious. The major aim of the present study was to assess whether NPC1 is involved in the delivery of...
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