Article

Solution structure of human STARD1 protein and its interaction with fluorescently-labeled cholesterol analogues with different position of the NBD-group

2017-03-14

Abstract excerpt

Intracellular cholesterol transfer to mitochondria, a bottleneck of adrenal and gonadal steroidogenesis, relies on the functioning of the steroidogenic acute regulatory protein (StAR, STARD1), for which many disease-associated mutations have been described. Despite significant progress in the field, the exact mechanism of cholesterol binding and transfer by STARD1 remains debatable, and the solution conformation o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6a3b7a2e-5cb2-553e-8ea0-99ba41155884
DOI: 10.1101/116368

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Solution structure of human STARD1 protein and its interaction with fluorescently-labeled cholesterol analogues with different position of the NBD-groupDOI 10.1101/116368Read

The mechanism of specific binding of free cholesterol by the steroidogenic acute regulatory protein: evidence for a role of the C-terminal alpha-helix in the gating of the binding site.Semantic proximity Read

Insights into steroidogenic acute regulatory protein (StAR)-dependent cholesterol transfer in mitochondria: evidence from molecular modeling and structure-based thermodynamics supporting the existence of partially unfolded states of StAR.Semantic proximity Read

New molecular insights into the A218V variant impact on the steroidogenic acute regulatory protein (STAR) associated with 46, XY disorders of sexual development.Semantic proximity Read

STAR/STARD1: a mitochondrial intermembrane space cholesterol shuttle degraded through mitophagySemantic proximity Read

Steroidogenic acute regulatory protein binds cholesterol and modulates mitochondrial membrane sterol domain dynamics.Semantic proximity Read

Toward the NMR structure of StAR.Semantic proximity Read

Cryo-EM structures of the ABCA4 importer reveal mechanisms underlying substrate binding and Stargardt disease.Semantic proximity Read

Molecular basis for the recognition of steroidogenic acute regulatory protein by the 14-3-3 protein family.Semantic proximity Read

Steroidogenic acute regulatory protein: an update on its regulation and mechanism of action.Semantic proximity Read

Integrative modelling of the full-length human dehydrodolichyl diphosphate synthase using a hybrid computational and experimental approachSemantic proximity Read

Endogenous and fluorescent sterols reveal the molecular basis for ligand selectivity of human sterol transportersSemantic proximity Read

Structures of the human peroxisomal fatty acid transporter ABCD1 in a lipid environmentSemantic proximity Read