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Dissecting the Genetic Link Between Insulin Resistance and Coronary Heart Disease: A Multi-Trait GWAS and Proteomic-Metabolomic Mediation Analysis

2026-08-03

Abstract excerpt

Insulin resistance (IR) is a hallmark feature of Type 2 Diabetes Mellitus and a well-established risk factor for coronary heart disease (CHD), yet the pathways through which IR contributes to CHD remain incompletely understood. To comprehensively describe the genetic architecture of IR, we collected three direct IR indicators---fasting insulin (N = 151,013), the Modified Stumvoll insulin sensitivity index (N = 53,...

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Literature Corpus work
e088599f-03d5-5a90-be80-3979ea0725be
DOI
10.64898/2026.08.02.26359507
Open publication

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Dissecting the Genetic Link Between Insulin Resistance and Coronary Heart Disease: A Multi-Trait GWAS and Proteomic-Metabolomic Mediation AnalysisDOI 10.64898/2026.08.02.26359507
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