Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multiomic integration analysis identifies atherogenic metabolites mediating between novel immune genes and cardiovascular risk.

Genome medicine - 24 Oct 2024

Carreras-Torres Robert, Galván-Femenía Iván, Farré Xavier, Cortés Beatriz, Díez-Obrero Virginia, Carreras Anna, Moratalla-Navarro Ferran, Iraola-Guzmán Susana, Blay Natalia, Obón-Santacana Mireia, Moreno Víctor, de Cid Rafael

Abstract excerpt

BACKGROUND: Understanding genetic-metabolite associations has translational implications for informing cardiovascular risk assessment. Interrogating functional genetic variants enhances our understanding of disease pathogenesis and the development and optimization of targeted interventions. METHODS: In this study, a total of 187 plasma metabolite levels were profiled in 4974 individuals of European ancestry of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Atherosclerosis
Share to Atherosclerosis and Cardiovascular Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cardiovascular Diseases

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Heart Disease Risk Factors

Share to Metabolome

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 39449064
DOI: 10.1186/s13073-024-01397-2
PMCID: PMC11515386

Genes

GCAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiomic integration analysis identifies atherogenic metabolites mediating between novel immune genes and cardiovascular risk.PMID 39449064Read ↗

An interaction map of circulating metabolites, immune gene networks and their genetic regulationSemantic proximity Read ↗

An interaction map of circulating metabolites, immune gene networks, and their genetic regulation.Semantic proximity Read ↗

A unified framework identifies new links between plasma lipids and diseases from electronic medical records across large-scale cohorts.Semantic proximity Read ↗

Genetic causality of circulating inflammatory proteins and plasma metabolites in coronary atherosclerosis.Semantic proximity Read ↗

Genetic associations of circulating plasma proteins with cardiometabolic diseases.Semantic proximity Read ↗

Epigenetic Regulation of ITGB7 Promotes Coronary Heart Disease via Immune and Metabolic Pathways: A Multimodal Mendelian Randomization Study.Semantic proximity Read ↗

Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids.Semantic proximity Read ↗

Proteome-wide Mendelian randomization identifies candidate causal proteins for cardiovascular diseasesSemantic proximity Read ↗

Dissecting the Genetic Link Between Insulin Resistance and Coronary Heart Disease: A Multi-Trait GWAS and Proteomic-Metabolomic Mediation AnalysisSemantic proximity Read ↗

Genetic determinants of blood gene expression and splicing and their contribution to molecular phenotypes and health outcomesSemantic proximity Read ↗

Multi-Omics Integration Improves Polygenic Risk Prediction for Lipid Traits: A Multi-Ancestry Study in UK Biobank.Semantic proximity Read ↗

Therapeutic protein targets for cardiometabolic diseases: Mendelian randomization integrating plasma proteomes with genome-wide association dataSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.