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Article

Proteomic Pathways Linking Type 2 Diabetes Genetic Clusters to Cardiovascular Diseases: A Network Mendelian Randomisation Study.

Diabetes, obesity & metabolism - 1 Nov 2026

Liao Shuang, Sung Gabriel Chun Yin, Liang Yiwen, Li Chenxi, Au Yeung Shiu Lun

Abstract excerpt

BACKGROUND: Genetic clusters related to Type 2 diabetes (T2D) have differential impact on cardiovascular diseases (CVDs), although the underlying mechanisms, such as proteomic perturbation, remain unexplored. We conducted a network Mendelian randomisation (MR) study to identify proteomic mediators linking T2D genetic clusters and CVDs. METHODS: We assessed the associations between genetic liability to T2D and...

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Identifiers

PMID: 42638160
DOI: 10.1111/dom.71253
PMCID: PMC13646353

Genes

ADH1B
APOC3
F11
KLKB1

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