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Article

Exploring the pathways linking fasting insulin to coronary artery disease: a proteome-wide Mendelian randomization study.

BMC medicine - 30 May 2025

Huang Xin, Zhao Jie V

Abstract excerpt

BACKGROUND: Insulin is known to be associated with a higher risk of coronary artery disease (CAD), but molecular mechanisms remain unclear. This study aimed to explore protein-mediated pathways linking fasting insulin to CAD using Mendelian randomization (MR). METHODS: This MR study examined the association between fasting insulin and CAD using genome-wide association study (GWAS) data from MAGIC and...

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Identifiers

PMID: 40442727
DOI: 10.1186/s12916-025-04127-6
PMCID: PMC12124044

Genes

CAD
AGRP
GZMA
LDLR
PLA2G7
HHEX

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