Article

Chemical inhibition of RPA gap protection sensitizes BRCA1-deficient cancers to PARP inhibition

2025-04-15

Abstract excerpt

Poly (ADP-ribose) polymerase inhibitors (PARPi) are standard of care for many BRCA1 deficient cancers, though few cures are achieved. We sought to determine if targeting the protection of the single-strand DNA gaps induced by PARPi in BRCA-deficient cancers could increase efficacy. Replication protein A (RPA) participates in critical protein-protein and protein-DNA interactions to protect single-stranded DNA (ssDN...

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Literature Corpus work: 32e1e6ea-b75c-5708-9f13-d247f093972e
DOI: 10.1101/2025.04.09.647957

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