Article

The oncoprotein DEK affects the outcome of PARP1/2 inhibition during replication stress

2019-02-19

Abstract excerpt

<h4>ABSTRACT</h4> DNA replication stress is a major source of genomic instability and is closely linked to tumor formation and progression. Poly(ADP-ribose)polymerases1/2 (PARP1/2) enzymes are activated in response to replication stress resulting in poly(ADP-ribose) (PAR) synthesis. PARylation plays an important role in the remodelling and repair of impaired replication forks, providing a rationale for targeting...

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Literature Corpus work: 3748e085-c992-53a4-8c3d-89046094a960
DOI: 10.1101/555003

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