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<i>In situ</i> generation of Aβ <sub>42</sub> oligomers via secondary nucleation triggers neurite degeneration and synaptic dysfunction in human iPSC-derived glutamatergic neurons

2024-09-01

Abstract excerpt

The aggregation of Aβ42 into misfolded oligomers is a central event in the pathogenesis of Alzheimer’s disease. In this study, we aimed to develop a robust experimental system that recapitulates Aβ42 oligomerization in living cells to gain insight into their neurotoxicity and to provide a platform to characterize the effects of inhibitors of this process. Our strategy is based on the in situ generation of Aβ42 ol...

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Identifiers and source

Literature Corpus work
e07d67a1-aca9-5e4f-85f7-7edea1fb6bc6
DOI
10.1101/2024.08.30.610591
Open publication

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<i>In situ</i> generation of Aβ <sub>42</sub> oligomers via secondary nucleation triggers neurite degeneration and synaptic dysfunction in human iPSC-derived glutamatergic neuronsDOI 10.1101/2024.08.30.610591
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