Article

Mechanism of Cellular Formation and In Vivo Seeding Effects of Hexameric β-amyloid Assemblies

2021-06-07

Abstract excerpt

<title>Abstract</title> <p>The β-amyloid peptide (Aβ) is the main constituent of senile plaques, a typical hallmark of Alzheimer’s disease (AD). Monomeric Aβ is generated through sequential processing of the amyloid precursor protein (APP), with a final step involving γ-secretase activity. In AD, Aβ monomers assemble in oligomers and ultimately fibrils depositing in plaques. Importantly, Aβ toxicity appears relat...

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Literature Corpus work: e6d1fc19-8a8b-51a8-813f-10dae7b64492
DOI: 10.21203/rs.3.rs-550136/v1

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