Article
Cellular transformation by combined lineage conversion and oncogene expression
2019-01-22
Abstract excerpt
Cancer is the most complex genetic disease known, with mutations implicated in more than 250 genes. However, it is still elusive which specific mutations found in human patients lead to tumorigenesis. Here we show that a combination of oncogenes that is characteristic of liver cancer (CTNNB1, TERT, MYC) induces senescence in human fibroblasts and primary hepatocytes. However, reprogramming fibroblasts to a liver p...
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Identifiers and source
- Literature Corpus work
- e0758c83-2d68-512c-a465-bd2e59bb96f0
- DOI
- 10.1101/525600