Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MYC determines lineage commitment in KRAS-driven primary liver cancer development

9 Mar 2023

Abstract excerpt

BACKGROUND & AIMS: Primary liver cancer (PLC) comprises hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA), two frequent and lethal tumour types that differ regarding their tumour biology and responses to cancer therapies. Liver cells harbour a high degree of cellular plasticity and can give rise to either HCC or iCCA. However, little is known about the cell-intrinsic mechanisms directing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cholangiocarcinoma and Gallbladder Cancer Studies
Share to FOXO transcription factor regulation
Share to Liver physiology and pathology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36906109
DOI: 10.1016/j.jhep.2023.02.039

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MYC determines lineage commitment in KRAS-driven primary liver cancer developmentPMID 36906109Read ↗

Cellular heterogeneity and transcriptomic profiles during intrahepatic cholangiocarcinoma initiation and progressionSemantic proximity Read ↗

Multiple cellular origins and molecular evolution of intrahepatic cholangiocarcinoma.Semantic proximity Read ↗

Genome-wide profiling of transcription factor activity in primary liver cancer using single-cell ATAC sequencingSemantic proximity Read ↗

Hepatocellular Carcinomas Originate Predominantly from Hepatocytes and Benign Lesions from Hepatic Progenitor CellsSemantic proximity Read ↗

Central Role of c-Myc during Malignant Conversion in Human HepatocarcinogenesisSemantic proximity Read ↗

Oncogenic driver genes and tumor microenvironment determine the type of liver cancerSemantic proximity Read ↗

Genetic Screens Identify a Context-Specific PI3K/p27Kip1 Node Driving Extrahepatic Biliary CancerSemantic proximity Read ↗

Integrative multiomics enhancer activity profiling identifies therapeutic vulnerabilities in cholangiocarcinoma of different etiologiesSemantic proximity Read ↗

Oncogenic Determination of a Broad Spectrum of Phenotypes of Hepatocyte-Derived Mouse Liver Tumors.Semantic proximity Read ↗

Cellular transformation by combined lineage conversion and oncogene expressionSemantic proximity Read ↗

Cholangiocytic differentiation drives cell proliferation in hepatoblastoma through Wnt-dependent FGF19 signalingSemantic proximity Read ↗

Identification and validation of functional roles for three MYC-associated genes in hepatocellular carcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.