Article
Titration of RAS alters senescent state and influences tumour initiation.
Nature - 1 Sept 2024
Chan Adelyne S L, Zhu Haoran, Narita Masako, Cassidy Liam D, Young Andrew R J, Bermejo-Rodriguez Camino, Janowska Aleksandra T, Chen Hung-Chang, Gough Sarah, Oshimori Naoki, Zender Lars, Aitken Sarah J, Hoare Matthew, Narita Masashi
Abstract excerpt
Oncogenic RAS-induced senescence (OIS) is an autonomous tumour suppressor mechanism associated with premalignancy1,2. Achieving this phenotype typically requires a high level of oncogenic stress, yet the phenotype provoked by lower oncogenic dosage remains unclear. Here we develop oncogenic RAS dose-escalation models in vitro and in vivo, revealing a RAS dose-driven non-linear continuum of downstream phenotypes....
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