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Article

Hacking cell differentiation: transcriptional rerouting in reprogramming, lineage infidelity and metaplasia.

EMBO molecular medicine - 1 Aug 2013

Regalo Gonçalo, Leutz Achim

Abstract excerpt

Initiating neoplastic cell transformation events are of paramount importance for the comprehension of regeneration and vanguard oncogenic processes but are difficult to characterize and frequently clinically overlooked. In epithelia, pre-neoplastic transformation stages are often distinguished by the appearance of phenotypic features of another differentiated tissue, termed metaplasia. In haemato/lymphopoietic...

Topics

Animals
Cell Differentiation
Cell Lineage
Cell Transformation, Neoplastic
Epigenesis, Genetic
Hematopoiesis
Humans
Leukemia
Lymphoma
Metaplasia
Mice
Phenotype

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Transcription Factors

Transcription, Genetic

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Identifiers

PMID: 23828660
DOI: 10.1002/emmm.201302834
PMCID: PMC3944458

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