Article

Titration of oncogenic RAS alters senescent state and influences tumour initiation

2023-04-25

Abstract excerpt

<title>Abstract</title> <p>Oncogenic RAS-induced senescence (OIS) is an autonomous tumour suppressor mechanism associated with pre-malignancy<sup>1-3</sup>. Achieving this phenotype typically requires a high level of oncogenic stress, yet the phenotype provoked by lower oncogenic dosage remains unclear. Here we develop oncogenic RAS-dose escalation models in vitro and in vivo, revealing a RAS-dose-driven non-line...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4d3b4c79-e69f-59e1-ac6b-ce1ba11e8fb6
DOI: 10.21203/rs.3.rs-2842963/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Titration of oncogenic RAS alters senescent state and influences tumour initiationDOI 10.21203/rs.3.rs-2842963/v1Read

Titration of RAS alters senescent state and influences tumour initiation.Semantic proximity Read

Exploring Senescence-Related Transcriptional Signatures to Uncover Molecular Subtypes and Key Genes in Hepatocellular CarcinomaSemantic proximity Read

Transformed cells after senescence give rise to more severe tumor phenotypes than transformed non-senescent cells.Semantic proximity Read

Multi range ERK responses shape the proliferative trajectory of single cells following oncogene induced senescenceSemantic proximity Read

RAS: Striking at the Core of the Oncogenic CircuitrySemantic proximity Read

Multi-range ERK responses shape the proliferative trajectory of single cells following oncogene induction.Semantic proximity Read

Oncogene inactivation-induced senescence facilitates tumor relapseSemantic proximity Read

A senescence restriction point acting on chromatin integrates oncogenic signalsSemantic proximity Read

Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis.Semantic proximity Read

Cellular transformation by combined lineage conversion and oncogene expressionSemantic proximity Read

Ras-Induced Senescence and its Physiological Relevance in CancerSemantic proximity Read

Zebrafish imaging reveals TP53 mutation switching oncogene-induced senescence from suppressor to driver in primary tumorigenesis.Semantic proximity Read