Genomic progression in mouse models for liver tumors.

doi:10.1101/sqb.2005.70.058

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Article

Genomic progression in mouse models for liver tumors.

Cold Spring Harbor symposia on quantitative biology - 1 Jan 2005

Tward A D, Jones K D, Yant S, Kay M A, Wang R, Bishop J M

Abstract excerpt

The principal cause of human liver cancer is infection with hepatitis viruses B and C, but tumor progression is fueled by ensuing perturbations that confer gain of function on proto-oncogenes or loss of function on tumor suppressor genes. Frequent among these perturbations is overexpression of the proto-oncogene MET. We have modeled the pathogenesis of liver tumors by expressing conditional transgenes of MET in...

Topics

Amino Acid Sequence
Animals
Disease Models, Animal
Gene Expression Regulation, Neoplastic
Humans
Liver Neoplasms, Experimental
Mice
Mice, Transgenic
Molecular Sequence Data
Mutation
Proto-Oncogene Mas
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-met
Proto-Oncogenes
Receptors, Growth Factor
Transfection
beta Catenin

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PMID: 16869757
DOI: 10.1101/sqb.2005.70.058

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