Article

Regulation of PP2A, PP4, and PP6 holoenzyme assembly by carboxyl-terminal methylation

2021-11-07

Abstract excerpt

The family of Phosphoprotein Phosphatases (PPPs) is responsible for most cellular serine and threonine dephosphorylation. PPPs achieve substrate specificity and selectivity by forming multimeric holoenzymes. PPP holoenzyme assembly is tightly controlled, and changes in the cellular repertoire of PPPs are linked to human disease, including cancer and neurodegeneration. For PP2A, PP4, and PP6, holoenzyme formation i...

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Literature Corpus work: e06cd917-8623-5882-ba00-7121942951f6
DOI: 10.1101/2021.11.07.467570

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