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Article

Effects of carboxyl-terminal methylation on holoenzyme function of the PP2A subfamily.

Biochemical Society transactions - 30 Oct 2020

Nasa Isha, Kettenbach Arminja N

Abstract excerpt

Phosphoprotein Phosphatases (PPPs) are enzymes highly conserved from yeast and human and catalyze the majority of the serine and threonine dephosphorylation in cells. To achieve substrate specificity and selectivity, PPPs form multimeric holoenzymes consisting of catalytic, structural/scaffolding, and regulatory subunits. For the Protein Phosphatase 2A (PP2A)-subfamily of PPPs, holoenzyme assembly is at least in...

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Identifiers

PMID: 33125487
DOI: 10.1042/BST20200177
PMCID: PMC8380034

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