Article

The Interplay of Acetylation and Ubiquitination Controls PRMT1 Homeostasis

2024-06-18

Abstract excerpt

PRMT1 plays many important roles in both normal and disease biology, thus understanding it’s regulation is crucial. Herein, we report the role of p300-mediated acetylation at K228 in triggering PRMT1 degradation through FBXL17-mediated ubiquitination. Utilizing mass-spectrometry, cellular biochemistry, and genetic code-expansion technologies, we elucidate a crucial mechanism independent of PRMT1 transcript levels....

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Literature Corpus work: c4143f0e-7497-55b2-b0d3-e3ba86943066
DOI: 10.1101/2024.06.18.599616

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