Article

STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation

2019-10-29

Abstract excerpt

Alterations involving serine-threonine phosphatase PP2A subunits occur in a range of human cancers and partial loss of PP2A function contributes to cell transformation. Displacement of regulatory B subunits by the SV40 Small T antigen (ST) or mutation/deletion of PP2A subunits alters the abundance and types of PP2A complexes in cells, leading to transformation. Here we show that ST not only displaces common PP2A B...

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Literature Corpus work: b297eb8e-7e9a-59bb-a21a-493ceb3fa3ae
DOI: 10.1101/823096

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