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Article

Protein Phosphatase 2A (PP2A) mutations in brain function, development, and neurologic disease.

Biochemical Society transactions - 27 Aug 2021

Verbinnen Iris, Vaneynde Pieter, Reynhout Sara, Lenaerts Lisa, Derua Rita, Houge Gunnar, Janssens Veerle

Abstract excerpt

By removing Ser/Thr-specific phosphorylations in a multitude of protein substrates in diverse tissues, Protein Phosphatase type 2A (PP2A) enzymes play essential regulatory roles in cellular signalling and physiology, including in brain function and development. Here, we review current knowledge on PP2A gene mutations causally involved in neurodevelopmental disorders and intellectual disability, focusing on...

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PMID: 34241636
DOI: 10.1042/BST20201313

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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