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Article

Cryo-EM structure of the Hippo signaling integrator human STRIPAK.

Nature structural & molecular biology - 1 Mar 2021

Jeong Byung-Cheon, Bae Sung Jun, Ni Lisheng, Zhang Xuewu, Bai Xiao-Chen, Luo Xuelian

Abstract excerpt

The striatin-interacting phosphatase and kinase (STRIPAK) complex is a large, multisubunit protein phosphatase 2A (PP2A) assembly that integrates diverse cellular signals in the Hippo pathway to regulate cell proliferation and survival. The architecture and assembly mechanism of this critical complex are poorly understood. Using cryo-EM, we determine the structure of the human STRIPAK core comprising PP2AA,...

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Identifiers

PMID: 33633399
DOI: 10.1038/s41594-021-00564-y
PMCID: PMC8315899

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