Article
Protein phosphatase 2A - structure, function and role in neurodevelopmental disorders.
Journal of cell science - 1 Jul 2021
Sandal Priyanka, Jong Chian Ju, Merrill Ronald A, Song Jianing, Strack Stefan
Abstract excerpt
Neurodevelopmental disorders (NDDs), including intellectual disability (ID), autism and schizophrenia, have high socioeconomic impact, yet poorly understood etiologies. A recent surge of large-scale genome or exome sequencing studies has identified a multitude of mostly de novo mutations in subunits of the protein phosphatase 2A (PP2A) holoenzyme that are strongly associated with NDDs. PP2A is responsible for at...
Topics
- Animals
- Humans
- Intellectual Disability
- Mutation
- Phosphorylation
- Protein Phosphatase 2
- Protein Subunits