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Article

Arid1b haploinsufficiency in excitatory neurons alters neocortical circuits but not social behavior or seizure phenotypes.

Experimental neurology - 1 Dec 2026

Marshall Alec H, Hanson Meretta A, Gage Danielle J, Nagarajan Devipriyanka, Bibi Noor, Fitzgerald Julie, Gaitten Emilee, Kokiko-Cochran Olga N, Gu Bin, Wester Jason C

Abstract excerpt

Arid1b is a high confidence risk gene for autism spectrum disorder that encodes a subunit of a chromatin remodeling complex initially expressed in neuronal progenitors. Haploinsufficiency causes a broad range of social, behavioral, and intellectual disability phenotypes, including Coffin-Siris syndrome. Recent work suggests pathology is due to deficits in proliferation, survival, and synaptic development of...

Read the complete abstract on PubMed

Topics

Animals
Transcription Factors
DNA-Binding Proteins
Haploinsufficiency
Mice, Transgenic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mice

Seizures

Social Behavior

Neocortex

Neurons

Phenotype

Male

Female

Nerve Net

Source

Identifiers

PMID: 42532136
DOI: 10.1016/j.expneurol.2026.115950

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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