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Loss-of-function variants in the schizophrenia risk gene <i>SETD1A</i> alter neuronal network activity in human neurons through cAMP/PKA pathway

2021-05-25

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<h4>Summary</h4> Heterozygous loss-of-function (LoF) mutations in SETD1A , which encodes a subunit of histone H3 lysine 4 methyltransferase, were shown to cause a novel neurodevelopmental syndrome and increase the risk for schizophrenia. We generated excitatory/inhibitory neuronal networks from human induced pluripotent stem cells with a SETD1A heterozygous LoF mutation ( SETD1A +/- ) using CRISPR/Cas9. Our da...

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Literature Corpus work
d21f1fe1-65e0-552c-9c65-91121646adf2
DOI
10.1101/2021.05.25.445613
Open publication

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Loss-of-function variants in the schizophrenia risk gene <i>SETD1A</i> alter neuronal network activity in human neurons through cAMP/PKA pathwayDOI 10.1101/2021.05.25.445613
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