Article

Axonopathy and altered synaptic development in early hippocampal epileptogenesis of Dravet syndrome

2023-10-05

Abstract excerpt

Dravet syndrome caused by SCN1A variants is a severe developmental epileptic encephalopathy (DEE) characterized by pharmaco-resistant epileptic seizures and progressive neurodevelopmental decline with cognitive impairment and autism-spectrum-traits. Numerous preceding studies indicate that the initial pathophysiology due to impaired Na V 1.1 function mainly derives from reduced interneuron firing leading to a ne...

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Literature Corpus work: 79ed2060-d270-599b-b2f3-6336e08f4d00
DOI: 10.1101/2023.10.04.560735

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