Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Intellectual disability-causing mutations in KIF11 impair microtubule dynamics and dendritic arborization.

Nature communications - 18 Mar 2026

Wingfield Jenna L, Niese Lukas, Avchalumov Yosef, Liu Xiaodan, Grover Rahul, Nakahata Yoshihisa, Raveendra Bindu L, Gonzalez-Santiago Adrian E, Carter Jackson P, Yasuda Ryohei, Yuan Jason X-J, Diez Stefan, Puthanveettil Sathyanarayanan V

Abstract excerpt

Microcephaly with or without chorioretinopathy, lymphedema, or intellectual disabilities (MCLID) is a rare disease caused by mutations in the mitotic motor KIF11. However, the specific neuronal functions of KIF11, its mechanisms of microtubule (MT) regulation, and the impact of MCLID mutations on KIF11 function remain underexplored. Here, using live-imaging, we find that KIF11 depletion in postmitotic neurons...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Axons
Share to Dendrites

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intellectual Disability

Share to Kinesins

Share to Microtubules

Share to Mutation

Share to Neurons

Source

Open in PubMed Open full text

Identifiers

PMID: 41844639
DOI: 10.1038/s41467-026-70522-z
PMCID: PMC13149629

Genes

KIF11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intellectual disability-causing mutations in KIF11 impair microtubule dynamics and dendritic arborization.PMID 41844639Read ↗

Traffic Jams in the Brain: How Kinesin Dysfunction Shapes Neurodevelopmental DisordersSemantic proximity Read ↗

Mutations in KIF11 cause autosomal-dominant microcephaly variably associated with congenital lymphedema and chorioretinopathy.Semantic proximity Read ↗

Pathogenic KIF1A variants differentially disrupt axonal trafficking and impede synaptic developmentSemantic proximity Read ↗

Distinct Clinical Phenotypes in KIF1A-Associated Neurological Disorders Result from Different Amino Acid Substitutions at the Same Residue in KIF1ASemantic proximity Read ↗

Tubulin CFEOM mutations both inhibit or activate kinesin motor activity.Semantic proximity Read ↗

A systems-level proteomic analysis identifies kinesin targets of KIFBP during neuronal developmentSemantic proximity Read ↗

Distinct Clinical Phenotypes in KIF1A-Associated Neurological Disorders Result from Different Amino Acid Substitutions at the Same Residue in KIF1A.Semantic proximity Read ↗

Cryo-EM Unveils the Processivity Mechanism of Kinesin KIF1A and the Impact of its Pathogenic Variant P305LSemantic proximity Read ↗

Genotype and defects in microtubule-based motility correlate with clinical severity in KIF1A-associated neurological disorderSemantic proximity Read ↗

Pathogenic KIF1A R350 Variants Disrupt A Conserved Kinesin-Tubulin Salt BridgeSemantic proximity Read ↗

Cryo-EM unveils kinesin KIF1A's processivity mechanism and the impact of its pathogenic variant P305L.Semantic proximity Read ↗

Pathogenic KIF1A R350 mutations disrupt a conserved and conformation-dependent kinesin-tubulin salt bridge.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.