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Article

Force generation of KIF1C is impaired by pathogenic mutations.

Current biology : CB - 12 Sept 2022

Siddiqui Nida, Roth Daniel, Toleikis Algirdas, Zwetsloot Alexander J, Cross Robert A, Straube Anne

Abstract excerpt

Intracellular transport is essential for neuronal function and survival. The most effective plus-end-directed neuronal transporter is the kinesin-3 KIF1C, which transports large secretory vesicles and endosomes.1-4 Mutations in KIF1C cause hereditary spastic paraplegia and cerebellar dysfunction in human patients.5-8 In contrast to other kinesin-3s, KIF1C is a stable dimer and a highly processive motor in its...

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Identifiers

PMID: 35961316
DOI: 10.1016/j.cub.2022.07.029
PMCID: PMC9631238

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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