Article

Force generation of KIF1C is impaired by pathogenic mutations

2021-06-30

Abstract excerpt

Intracellular transport is essential for neuronal function and survival. The fastest neuronal transporter is the kinesin-3 KIF1C. Mutations in KIF1C cause hereditary spastic paraplegia and cerebellar dysfunction in human patients. However, neither the force generation of the KIF1C motor protein, nor the biophysical and functional properties of pathogenic mutant proteins have been studied thus far. Here we show tha...

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Literature Corpus work: 36c79148-6692-558b-a703-d98cc35bccc4
DOI: 10.1101/2021.06.30.450611

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