Article

Tau directs intracellular trafficking by regulating the forces exerted by kinesin and dynein teams

2017-08-08

Abstract excerpt

Organelles, proteins, and mRNA are transported bidirectionally along microtubules by plus-end directed kinesin and minus-end directed dynein motors. Microtubules are decorated by microtubule-associated proteins (MAPs) that organize the cytoskeleton, regulate microtubule dynamics and modulate the interaction between motor proteins and microtubules to direct intracellular transport. Tau is a neuronal MAP that stabil...

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Identifiers and source

Literature Corpus work: 8317eed0-030e-590d-b012-11e3351a929e
DOI: 10.1101/173609

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