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Article

ADAR and hnRNPC deficiency synergize in activating endogenous dsRNA-induced type I IFN responses

25 Jun 2021

Abstract excerpt

Cytosolic double-stranded RNA (dsRNA) initiates type I IFN responses. Endogenous retroelements, notably Alu elements, constitute a source of dsRNA. Adenosine-to-inosine (A-to-I) editing by ADAR induces mismatches in dsRNA and prevents recognition by MDA5 and autoinflammation. To identify additional endogenous dsRNA checkpoints, we conducted a candidate screen in THP-1 monocytes and found that hnRNPC and ADAR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34297039
DOI: 10.1084/jem.20201833

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