Article

SLIRP promotes autoimmune diseases by amplifying antiviral signaling via positive feedback regulation

2024-04-02

Abstract excerpt

<h4>SUMMARY</h4> The abnormal innate immune response is a prominent feature underlying autoimmune diseases. One emerging factor that can trigger dysregulated immune activation is cytosolic mitochondrial double-stranded RNAs (mt-dsRNAs). However, the mechanism by which mt-dsRNAs stimulate immune responses remains poorly understood. Here, we discover SRA stem-loop interacting RNA binding protein (SLIRP) as a key am...

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Literature Corpus work: d83dbd03-ee61-5444-82a7-d4b6ec48c9f3
DOI: 10.1101/2024.03.28.587146

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