Article

Targeting MDA5 enhances tumor immunity through immunogenic cell death and augments the efficacy of immune checkpoint blockade

2025-12-09

Abstract excerpt

<title>Abstract</title> <p>Identifying targets to enhance tumor immunity is an urgent need. Although nucleic acid sensors play critical roles in promoting tumor immune clearance, their exceptionally low mutation rate in cancers suggests potential unexplored roles in tumor progression. Here, we demonstrated that the RNA sensor MDA5 promotes immune evasion, and its high expression was strongly predictive of poor su...

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Literature Corpus work: 620797db-6162-5845-875c-f84d4023d852
DOI: 10.21203/rs.3.rs-8094898/v1

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