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Article

Response of spatially defined microglia states with distinct chromatin accessibility in a mouse model of Alzheimer’s disease

14 Jul 2025

Abstract excerpt

Microglial spatial heterogeneity remains a crucial yet not fully answered question in the context of potential cell-directed therapies for Alzheimer's disease (AD). There is an unclear understanding of the dynamics of distinct microglia states adjacent to or far from amyloid-beta (Aβ) plaques and their contributions to neurodegenerative diseases. Here we combine multicolor fluorescence cell fate mapping,...

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PMID: 40659845
DOI: 10.1038/s41593-025-02006-0

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