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A Forward Genetic Screen in <i>Caenorhabditis elegans</i> for Genes that Modulate α-synuclein-Induced Neurodegeneration through the Mitochondrial UPR

2026-06-15

Abstract excerpt

Overexpression of α-synuclein (α-syn), an inherently disordered protein, triggers chronic activation of the mitochondrial unfolded protein response (UPR mt ) pathway in Caenorhabditis elegans with enhanced dopaminergic (DAergic) neurodegeneration. Introduction of a loss-of-function (lf) mutation in atfs-1 , the main transcriptional regulator of the UPR mt , into α-syn nematodes results in significant neuropro...

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Literature Corpus work
dfe2a17c-4406-5567-9fa8-d37cc827a6a6
DOI
10.64898/2026.06.11.731199
Open publication

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A Forward Genetic Screen in <i>Caenorhabditis elegans</i> for Genes that Modulate α-synuclein-Induced Neurodegeneration through the Mitochondrial UPRDOI 10.64898/2026.06.11.731199
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