Article

An atfs-1 loss-of-function screen identifies novel regulators of a-synuclein toxicity in C. elegans dopaminergic neurons

2026-08-21

Abstract excerpt

Overexpression of -synuclein (-syn), an inherently disordered protein, triggers chronic activation of the mitochondrial unfolded protein response (UPR mt ) pathway in Caenorhabditis elegans with enhanced dopaminergic (DAergic) neurodegeneration. Introduction of a loss-of-function (lf) mutation in atfs-1 , the main transcriptional regulator of the UPR mt , into -syn nematodes results in significant neuroprotec...

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Literature Corpus work: 3e99481c-c395-5a77-be05-b8f77ac42016
DOI: 10.64898/2026.08.17.745327

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