Article

Establishment and Characterization of a <i>CCND1</i> -Rearranged Non-Mantle Cell Lymphoma Cell Line and Patient-Derived Xenograft Model

2025-08-27

Abstract excerpt

The pathobiology of aggressive B-cell lymphomas with CCND1 rearrangements, distinct from Mantle Cell Lymphoma (MCL), presents a significant clinical challenge. These lymphomas are often difficult to diagnose and demonstrate resistance to standard immunochemotherapy, underscoring the urgent need for a deeper understanding of their underlying biology to develop more effective treatments. A major impediment to progr...

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Literature Corpus work: dfd4017a-22ac-5b0f-9c9c-c8c8f2d37f6b
DOI: 10.1101/2025.08.23.671479

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