Article

Establishment and Molecular Characterization of Patient-Derived Organoids for Primary Central Nervous System Lymphoma

2024-10-24

Abstract excerpt

Primary central nervous system lymphoma (PCNSL) exhibits substantial heterogeneity, both intra-tumoral and intertumoral, posing challenges in developing effective treatment methods. Existing in vitro models fail to simulate the inherent microenvironment and the cellular and mutational diversity of native tumors and require a prolonged generation time. To address this concern, we described an organoid culture metho...

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Literature Corpus work: 54865669-ac29-53c2-b634-98f66f4b4ca5
DOI: 10.1101/2024.10.21.619549

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