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Unraveling MCL biology to understand resistance and identify vulnerabilities

29 Mar 2024

Abstract excerpt

ABSTRACT: Mantle cell lymphoma (MCL) is a rare (5%-7%), aggressive B-cell non-Hodgkin lymphoma with well-defined hallmarks (eg, cyclin D1, SOX11), and its expansion is highly dependent on the tumor microenvironment (TME). Parallel drastic progress in the understanding of lymphomagenesis and improved treatments led to a paradigm shift in this B-cell malignancy with now prolonged disease-free survival after...

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PMID: 38551811
DOI: 10.1182/blood.2023022351

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