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Article

Diffuse large B-cell lymphoma patient-derived xenograft models capture the molecular and biological heterogeneity of the disease.

Blood - 5 May 2016

Chapuy Bjoern, Cheng Hongwei, Watahiki Akira, Ducar Matthew D, Tan Yuxiang, Chen Linfeng, Roemer Margaretha G M, Ouyang Jing, Christie Amanda L, Zhang Liye, Gusenleitner Daniel, Abo Ryan P, Farinha Pedro, von Bonin Frederike, Thorner Aaron R, Sun Heather H, Gascoyne Randy D, Pinkus Geraldine S, van Hummelen Paul, Wulf Gerald G, Aster Jon C, Weinstock David M, Monti Stefano, Rodig Scott J, Wang Yuzhuo, Shipp Margaret A

Abstract excerpt

Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease defined by transcriptional classifications, specific signaling and survival pathways, and multiple low-frequency genetic alterations. Preclinical model systems that capture the genetic and functional heterogeneity of DLBCL are urgently needed. Here, we generated and characterized a panel of large B-cell lymphoma (LBCL) patient-derived xenograft...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lymphoma, Large B-Cell, Diffuse

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Source

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Identifiers

PMID: 26773040
DOI: 10.1182/blood-2015-09-672352
PMCID: PMC4859195

Genes

BCR
BCL2
CARD11
CREBBP
GNA13
MYC
MYD88
PIM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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