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Article

The Novel Immunocompetent Eµ-SOX11CCND1 Mouse Model Phenotypically and Molecularly Resembles Human Mantle Cell Lymphoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 3 Nov 2025

Jafari Hedieh, Brown-Burke Fiona, Pray Betsy, Sloan Shelby, Helmig-Mason JoBeth, Hout Ian, Leon Sydney, Long Mackenzie, Chan Wing Keung, Hanel Walter, Corps Kara, Leshchenko Violetta V, Edwards Donna, Prakash Shukla Ravi, Reci Sidorela, Vaddi Kris, Scherle Peggy, Collier Paul, La Ferlita Alessandro, Singh Satishkumar, Distefano Rosario, Lapalombella Rosa, Sehgal Lalit, Faryabi Robert B, Meydan Cem, Mason Christopher E, Baiocchi Robert A, Parekh Samir, Alinari Lapo

Abstract excerpt

PURPOSE: Mantle cell lymphoma (MCL) remains incurable despite therapeutic advances, highlighting the need for improved preclinical models. Existing transgenic MCL mouse models have significant limitations, restricting their translational value. EXPERIMENTAL DESIGN: We generated an immunocompetent MCL model by overexpressing the key oncogenic drivers SRY-box transcription factor 11 (SOX11) and Cyclin D1 (CCND1)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40857109
DOI: 10.1158/1078-0432.CCR-25-0534
PMCID: PMC12442894

Genes

CCND1
SOX11
SRY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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