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Distinct Genetically Determined Origins of Myd88 / BCL2 -Driven Aggressive Lymphoma Rationalize Targeted Therapeutic Intervention Strategies

7 Nov 2022

Abstract excerpt

Genomic profiling revealed the identity of at least 5 subtypes of diffuse large B-cell lymphoma (DLBCL), including the MCD/C5 cluster characterized by aberrations in MYD88, BCL2, PRDM1, and/or SPIB. We generated mouse models harboring B cell-specific Prdm1 or Spib aberrations on the background of oncogenic Myd88 and Bcl2 lesions. We deployed whole-exome sequencing, transcriptome, flow-cytometry, and mass...

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PMID: 36346827
DOI: 10.1158/2643-3230.bcd-22-0007

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